Compositions and Methods for the Prevention and/or Reduction of Scarring
OwnerHoward Levinson, Kam W. Leong +2inventors
InventorsHoward Levinson, Kam W. Leong, Elizabeth R. Lorden, Kyle J. Miller
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Abstract
The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.
Claims21
1-20. (canceled)
A biocompatible scaffold comprising poly(l-lactide-co-ε-caprolactone) (PLCL), which is electrospun.
A method of preventing and/or reducing scarring of a wound in a subject, comprising implanting a biocompatible electrospun scaffold in the wound of the subject to promote granulation tissue formation and to prevent wound and scar contraction.
A method of preventing and/or reducing scar contracture in a wound in a subject, comprising implanting a biocompatible electrospun scaffold in the wound of the subject to minimize mechanical strain transmission and/or reduce ECM alignment and inflammation thereby preventing and/or reducing scar contracture.
Dependencies are inferred from the claim text.