Formulations for wound therapy
AssigneeMallinckrodt Pharma IP Trading D.A.C.
InventorsEliane Schutte, Linda Zuckerman, Richard Senderoff, Glen Martyn
Life of this patent
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Abstract
The present invention relates to novel formulations comprising a dry powder fibrin sealant comprised of a mixture of fibrinogen and/or thrombin, for use in the treatment of wounds or injuries, in particular for use as a topical hemostatic composition or for surgical intervention.
Claims8
A method of treating a wound or reducing bleeding at a haemorrhaging site, comprising administering to the wound or haemorrhaging site a pharmaceutical composition comprising an absorbable carrier of a biocompatible, biodegradable polymer and microparticles comprising fibrinogen in an amount of from about 0.1-15 mg/cm2 and/or microparticles comprising thrombin in an amount of from about 0.01 to 500 IU/cm2, wherein the microparticles further comprise a glassy carrier, and wherein the microparticles are attached to said absorbable carrier.
A method of making a pharmaceutical composition comprising:
- (i) suspending microparticles comprising fibrinogen and/or microparticles comprising thrombin, which microparticles further comprise a glassy carrier, in a vehicle in which they are not soluble;
- (ii) applying the resulting suspension to an absorbable carrier;
- and
- (iii) optionally removing the vehicle.
Dependencies are inferred from the claim text.