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US 2017/0304468 A1Published application
Upar targeting peptide for use in peroperative optical imaging of invasive cancer
AssigneeRigshospitalet
InventorsAndreas KJAER, Morten PERSSON
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Abstract
There is provided a novel conjugate that binds to the cell surface receptor uPA (uPAR). The conjugate is based on a fluorescence-labeled peptide useful as a diagnostic probe to the surfaces of cells expressing uPAR. The conjugate is capable of carrying a suitable detectable and imageable label that will allow qualitative detection and also quantitation of uPAR levels in vitro and in vivo. This renders the surgical resection of tumors more optimal.
Claims11
A fluorophor labelled u PAR-targeting peptide conjugate having the formula:
- X-Y-(D-Asp)-([beta]-cyclohexyl-L-alanine)-(Phe)-(D-Ser)-(D-Arg)-(Tyr)-(Leu)-(Trp)-(Ser)
- wherein,
- X represents imageable moiety capable of detection either directly or indirectly in a optical imaging procedure, and
- Y represents a spacer, a biomodifier or is absent
1 more element
Dependencies are inferred from the claim text.