Thiol-ene functionalized hydrogels
AssigneesMassachusetts Institute of Technology, Invivo Therapeutics Corporation
InventorsTimothy O'Shea, Alex A. Aimetti, Robert S. Langer
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Abstract
Disclosed herein are biodegradable hydrogel network containing covalently crosslinked bonds between oligomeric poly(thiol) compounds and oligomeric poly(Michael acceptors). The hydrogels do not substantially change shape upon exposure to aqueous solutions, and as such as suitable for local drug delivery to sensitive tissue areas.
Claims15
A biodegradable hydrogel network comprising at least one oligomeric poly(thiol) crosslinked with at least one oligomeric poly(Michael acceptor) having polymer weight fraction of at least 5% but no more than 40%, wherein after submersion in an aqueous solution having a pH of 7.4 at 37° C., the biodegradable hydrogel network is degraded within a period ranging from 5 to 60 days without substantially changing in shape, and wherein the network expels as little as 1% but no more than 60% of its curing weight in the water/buffer.
Dependencies are inferred from the claim text.