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US 2017/0304449 A1Published application
Non-aqueous patch
AssigneesITOCHU CHEMICAL FRONTIER Corporation, Oishi Koseido Co., Ltd.
InventorsTATSUYA MORI, NAOYUKI SAIDA
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AssigneesITOCHU CHEMICAL FRONTIER Corporation, Oishi Koseido Co., Ltd.
InventorsTATSUYA MORI, NAOYUKI SAIDA
Estimating the term…
Non-aqueous patches comprising lidocaine, which is not dissolved and is present in a crystalline state, have poor permeability to the skin. Therefore, non-aqueous patches have a high concentration of lidocaine. It is pointed out that lidocaine has an adverse effect on the heart. Prolonged use of a high concentration of lidocaine causes side effects, such as shock, rubor, and irritating sensation. External preparations comprising more than 5 mass % of lidocaine are designated as powerful drugs, and cannot be used as household (nonprescription) medicine. Provided is a non-aqueous patch that is effective to relieve muscle pain, the non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent composed of an organic acid and a polyalcohol, which are contained in a base.
A non-aqueous patch comprising 0.5 to 7 mass % lidocaine, and a dissolving agent consisting essentially of an organic acid and a polyalcohol, which are contained in a plaster, wherein the amount of lidocaine is 0.1 to 1 mg/cm2 of the plaster, and wherein the proportion of dissolving agent to lidocaine is 0.5 to 5 mass % of dissolving agent relative to 1 mass % of lidocaine.
(canceled)
Dependencies are inferred from the claim text.