Novel epitope as a target for therapy of inflammatory autoimmune diseases and graft rejection
AssigneeRappaport Family Institute for Research in the Medical Sciences
InventorsNathan KARIN, Gizi WILDBAUM
Life of this patent
Estimating the term…
Abstract
The present invention relates to a peptide comprising an epitope within the macrophage scavenger receptor B-I, a method of using the same, a nucleic acid encoding the same and an antibody that binds to the epitope.
Claims28
A peptide comprising the amino acid sequence set forth in EFYSPEACRSM (SEQ ID NO:
- 1) or EFFSPEACRSM (SEQ ID NO:
- 2) or any functionally related variant thereof.
-6. (canceled)
(canceled)
An antibody or antibody binding fragment or a functionally variant thereof, which recognizes or forms a molecular complex with the peptide set forth in SEQ ID NO:
- 1 SEQ ID NO;
- 2) or with a fragment thereof, on the surface of the macrophage scavenger receptor protein.
10-14. (canceled)
16-20. (canceled)
(canceled)
28-31. (canceled)
37-39. (canceled)
(canceled)
A method of treating an inflammatory and/or autoimmunity and/or neuroinflammation disease/s in a subject in need, the method comprising providing to the subject in need thereof a therapeutically effective amount of the pharmaceutical composition of claim
Dependencies are inferred from the claim text.