Nucleic acids for treatment of peanut allergies
AssigneeImmunomic Therapeutics, Inc.
InventorsWilliam HEARL, Teri HEILAND
Life of this patent
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Abstract
Provided herein are DNA vaccines for the treatment of peanut allergies. The vaccines comprise the coding sequence for one or more peanut allergenic epitopes fused in-frame with the luminal domain of the lysosomal associated membrane protein (LAMP) and the targeting sequence of LAMP. The vaccines can be multivalent molecules and/or can be provided as part of a multivalent vaccine comprising two or more DNA constructs.
Claims28
1-50. (canceled)
An isolated or purified nucleic acid molecule comprising, in sequential order:
- a nucleic acid sequence encoding a signal sequence;
- a nucleic acid sequence encoding an intra-organelle stabilizing/trafficking domain;
- a nucleic acid sequence encoding a peanut allergen domain, wherein the peanut allergen domain comprises at least one peanut allergen that does not include a native signal sequence for the peanut allergen;
- a nucleic acid sequence encoding a transmembrane domain;
- and
- a nucleic acid sequence encoding an endosomal/lysosomal targeting domain.
The method of 71, wherein the nucleic acid molecule is administered to the subject by intramuscular injection (IM) or intradermal (ID) injection.
Dependencies are inferred from the claim text.