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US 2017/0304430 A1Published application
Virus vector, cell, and construct
AssigneeKyushu University, National University Corporation
InventorsKenzaburo TANI, Takafumi HIRAMOTO, Makoto TAKEDA, Maino TAHARA
Life of this patent
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Abstract
A virus vector contains a genome that is derived from a virus belonging to the family Paramyxoviridae, and has a gene encoding a modified H protein, a gene encoding a modified F protein, and foreign genes. The genome may be segmented into multiple segments, and each genome segment may have a leader sequence and a trailer sequence.
Claims12
A virus vector, comprising a genome derived from a virus belonging to the family Paramyxoviridae in which both a gene encoding an H protein and a gene encoding an F protein are modified, wherein
- the genome contains a foreign gene.
A construct, containing
- a nucleic acid that is a template for multiple genome segments derived from a virus belonging to the family Paramyxoviridae, in which a leader sequence is located at the 3′ end and a trailer sequence is located at the 5′ end, respectively, wherein
- both the gene encoding the H protein and the gene encoding the F protein in the segmented genome are modified.
Dependencies are inferred from the claim text.