Novel targets of acinetobacter baumannii
AssigneeAridis Pharmaceuticals
InventorsSimon Urwyler, Markus Haake, Michael Rudolf
Life of this patent
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Abstract
The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
Claims17
A vaccine composition comprising at least one isolated polypeptide encoded by a nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- a) a polynucleotide having the nucleic acid sequence depicted in any one of SEQ ID NOs:
- 1, 3, 5, 7, 9, 11, 13 and 15;
- b) a polynucleotide encoding a fragment, analog or functional derivative of a polypeptide encoded by the polynucleotide of (a), wherein said fragment, analog or functional derivative has immunostimulatory activity;
- c) a polynucleotide encoding a polypeptide having an amino acid sequence that is at least 80% identical to the amino acid sequence depicted in any one of SEQ ID NOs:
- 2, 4, 6, 8, 10, 12, 14, and 16 and having immunostimulatory activity;
- d) a polynucleotide which is at least 80% identical to the polynucleotide of (a), and which encodes a polypeptide having immunostimulatory activity;
- e) a polynucleotide which hybridizes under stringent conditions to the polynucleotide of any one of (a) to (d);
- and
- f) a polynucleotide that is complementary to the full length of a polynucleotide of any of (a) to (d).
(canceled)
4-5. (canceled)
An isolated antigenic polypeptide consisting of an amino acid sequence depicted in any one of SEQ ID NOs:
- 2, 4, 6, 8, 10, 12, 14 and 16;
- or fragment, analog or functional derivative thereof, wherein said fragment, analog or functional derivative has immunostimulatory activity.
8-29. (canceled)
An isolated polypeptide for use in the treatment and/or prevention of a bacterial infection in a mammal encoded by a nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- a) a polynucleotide having the nucleic acid sequence depicted in any one of SEQ ID NOs:
- 1, 3, 5, 7, 9, 11, 13, and 15;
- b) a polynucleotide encoding a fragment, analog or functional derivative of a polypeptide encoded by the polynucleotide of (a), wherein said fragment, analog or functional derivative has immunostimulatory activity;
- c) a polynucleotide encoding a polypeptide having an amino acid sequence that is at least 80% identical to the amino acid sequence depicted in any one of SEQ ID NOs:
- 2, 4, 6, 8, 10, 12, 14, and 16 and having immunostimulatory activity;
- d) a polynucleotide which is at least 80% identical to the polynucleotide of (a), and which encodes a polypeptide having immunostimulatory activity;
- e) a polynucleotide which hybridizes under stringent conditions to the polynucleotide of any one of (a) to (d);
- and
- f) a polynucleotide that is the complement of the full length of a polynucleotide of any of (a) to (d).
(canceled)
Dependencies are inferred from the claim text.