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US 2017/0304413 A1Published application
Implantable matrix having optimum ligand concentrations
AssigneeWarsaw Orthopedic, Inc.
InventorVanja Margareta King
Life of this patent
Estimating the term…
Abstract
Implantable matrices and methods are provided. The matrices are configured to fit at or near a target tissue site, the matrices comprise biodegradable materials and ligands bound to the matrices and are configured to bind receptors and allow influx of cells into the implantable matrices, wherein the ratio of ligands to receptors is from about 1.5 to about 0.5.
Claims8
-12. (canceled)
A method for treating a target tissue site beneath the skin in a patient in need of such treatment, the method comprising administering an implantable matrix configured to fit at or near a target tissue site, the matrix comprising:
- a biodegradable collagen and a ligand comprising bone morphogenic protein bound to the matrix and configured to bind a receptor of progenitor, bone and/or cartilage cells and allow influx of the cells into the implantable matrix, wherein the ratio of ligand to receptor is from about 0.5 to about 1.5.
-20. (canceled)
Dependencies are inferred from the claim text.