Method for treating hyperglycemia with glp-1
AssigneeMannKind Corporation
InventorsDonald Costello, Peter Richardson, Robert A. Baughman, Mark T. Marino
Life of this patent
Estimating the term…
Abstract
A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
Claims13
An inhalable dry powder pharmaceutical composition comprising a therapeutically effective amount of an active agent and a diketopiperazine microparticle less than 10 μm in diameter;
- wherein said active agent comprises at least one of a vasoactive agent, a neuroactive agent, a hormone, an anticoagulant, an immunomodulating agent, a cytotoxic agent, an antibiotic, an antiviral agent, an antigen, or an antibody;
- and
- wherein said diketopiperazine comprises 3,6-di(N-X-4-aminobutyl)-2,5-diketopiperazine;
- wherein X is selected from the group consisting of succinyl, glutaryl, maleyl, and fumaryl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.