ANG-(1-7) Derivative Oligopeptides for the Treatment of Pain and Other Indications
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsMeredith Hay, John Konhilas, Robin L. Polt, Todd Vanderah, Brittany Forte, Tally Milnes, Evan Jones
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Abstract
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury.
Claims13
A method for providing analgesia to a subject having a painful condition comprising administering to the subject a therapeutically effective amount of an oligopeptide comprising an amino acid sequence consisting of the formula:
- A1-A2-A3-A4-A5-A6-A7-A8 (SEQ ID NO:1) wherein
- A1 is selected from the group consisting of aspartic acid, glutamic acid, alanine, and glycosylated forms thereof;
- A2 is selected from the group consisting of arginine, histidine, lysine, and glycosylated forms thereof;
- A3 is selected from the group consisting of valine, alanine, isoleucine, leucine, and glycosylated forms thereof;
- A4 is selected from the group consisting of tyrosine, phenylalanine, tryptophan, and glycosylated forms thereof;
- A5 is selected from the group consisting of isoleucine, valine, alanine, leucine, and glycosylated forms thereof;
- A6 is selected from the group consisting of histidine, arginine, lysine, and glycosylated forms thereof;
- A7 is selected from the group consisting of proline, glycine, serine, and glycosylated forms thereof;
- and
- A8 can be present or absent, wherein when A8 is present, A8 is selected from the group consisting of serine, threonine, hydroxyproline, and glycosylated forms thereof,
- wherein the amino acid sequence is not the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.