Methods of treating cervical cancer
AssigneeGenexine, Inc.
InventorsHyun-Tak JIN, HYE SEONG LIM, YOU SUK SUH, EUN JOO NAM
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Abstract
This invention relates to the treatment of cervical tumor caused by human papillomavirus (HPV) infection. In particular, the invention provides methods for improving cervical tumor treatment and methods for treating cervical tumor caused by HPV infection using a polynucleotide encoding an E6/E7 fusion protein.
Claims34
A pharmaceutical composition comprising a polynucleotide encoding a fusion protein for use in treating cervical tumor in a subject in need thereof, wherein the subject is to be administered a first dose of the composition to a subject in need thereof and is to be administered a second dose of the composition, wherein the subject exhibits an increased cellular immune response after administration of the first dose when measured, wherein the fusion protein comprises three or more amino acid sequences selected from:
- (1) an N-terminal portion of an E6 protein of HPV16,
- (2) a C-terminal portion of an E6 protein of HPV16,
- (3) an N-terminal portion of an E7 protein of HPV16,
- (4) a C-terminal portion of an E7 protein of HPV16,
- (5) an N-terminal portion of an E6 protein of HPV18,
- (6) a C-terminal portion of an E6 protein of HPV18,
- (7) an N-terminal portion of an E7 protein of HPV18, and
- (8) a C-terminal portion of an E7 protein of HPV18,
- wherein the fusion protein does not bind to p53 or does not form a dimer with an E6 protein of HPV16 or HPV 18 and wherein the fusion protein does not bind to pRb or does not form a dimer with an E7 protein of HPV16 or HPV18.
Dependencies are inferred from the claim text.