Capsule for the oral administration of biopharmaceuticals
AssigneeSymbiotic Health Inc.
InventorsGerard Honig, Joaquin Urdinez, Chandrabali Ghose
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Abstract
In one embodiment the invention provides a capsule for the oral administration of biopharmaceuticals to the gastrointestinal system. The capsule includes a capsule shell enveloping a lipophilic matrix permeated with discrete microcapsules. Each microcapsule is a hydrophilic matrix formed of an internal phase comprising an aqueous medium, stabilized into a discrete structure by a colloidal polymer, and containing the biopharmaceutical(s). The colloidal polymer typically is a hydrocolloid or an amphiphilic colloidal polymer.
Claims64
A therapeutic capsule for the oral administration of a biopharmaceutical to the gastrointestinal system comprising a capsule shell enveloping a lipophilic matrix permeated with microcapsules, wherein each microcapsule comprises a hydrophilic matrix formed from an aqueous medium, stabilized into a discrete structure by a colloidal polymer, and contains the biopharmaceutical.
A therapeutic capsule for the oral administration of a biopharmaceutical to the gastrointestinal system comprising a capsule shell enveloping a lipophilic matrix permeated with discrete microcapsules, wherein each microcapsule comprises a hydrophilic matrix formed from an internal phase comprising an aqueous medium, stabilized into a discrete structure by a colloidal polymer, and contains bacteria.
A process for making a therapeutic capsule for the oral administration of a biopharmaceutical to the gastrointestinal system comprising the steps of:
- a. suspending the biopharmaceutical in an isotonic solution containing a colloidal polymer;
- b. forming microspheres comprising the colloidal polymer, wherein the polymer forms an internal phase that entraps the biopharmaceutical;
- c. recovering and drying the microspheres;
- d. suspending the microspheres in a lipophilic matrix to form a slurry;
- and,
- e. packing a capsule with the slurry,
- f. wherein the colloidal polymer is selected from the group consisting of hydrocolloid colloidal polymers and amphiphilic colloidal polymers.
Dependencies are inferred from the claim text.