Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
AssigneeCedars-Sinai Medical Center
InventorsEduardo Marban, Geoffrey DeCouto, Eleni Tseliou
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Abstract
Described herein are compositions and techniques related to generation and therapeutic application of stem cell-derived exosomes. The Inventors have discovered cardiosphere-derived cells (CDCs) and their secreted exosomes mediate such inflammatory processes, by, for example, shifting macrophages away from a proinflammatory M1 phenotype toward M2 healing phenotype. This suggests compositions and techniques for use in both long-term reversal of heart and vascular disease pathology, and protection against such disease progression via modulation of inflammation and immune responses.
Claims27
1-33. (canceled)
A method of modulating inflammation, comprising:
- administering a composition comprising a plurality of exosomes to a subject afflicted with an inflammatory related disease or condition, wherein administration of the composition modulates inflammation in the subject by polarizing a population of macrophages in the subject.
A method of conferring cardioprotection, comprising:
- administering a composition comprising a plurality of exosomes to a subject afflicted with myocardial infarct (MI), ischemia/reperfusion (IR), or both, wherein administration of the composition confers cardioprotection by polarizing a population of macrophages in the subject.
An in vitro method of altering a cell, comprising:
- providing a plurality of exosomes;
- and
- adding to a starting cell type, the plurality of exosomes, wherein adhesion between exosomes in the plurality of exosomes and the starting cell type is capable of altering one or more properties of the starting cell type, and generating a converted cell type.
Dependencies are inferred from the claim text.