Method for treating constipation
AssigneeGelesis LLC
InventorsAlessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Abstract
The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.
Claims36
A method for treating constipation in a subject in need thereof, comprising the step of orally administering to the subject a therapeutically effective amount of a crosslinked carboxymethylcellulose, which is produced by a method comprising crosslinking carboxymethylcellulose, wherein said carboxymethylcellulose has a viscosity as a 1% (wt/wt) aqueous solution at 25° C. of greater than 6000 cps.
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A pharmaceutical composition comprising (a) a crosslinked carboxymethylcellulose, which is produced by a method comprising crosslinking carboxymethylcellulose, wherein said carboxymethylcellulose has a viscosity as a 1% (wt/wt) aqueous solution at 25° C. of greater than 6000 cps;
- and (b) a second therapeutic agent for constipation.
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Dependencies are inferred from the claim text.