Combination therapy for the treatment of depression and other non-infectious diseases

A method for treating a mood disorder in a subject in need thereof, the method consisting essentially of the step of administering to the subject a therapeutically effective amount of a pharmaceutical composition containing as a sole active agent, an agent which consists essentially of a combination of:

• (a) methylsulfonylmethane or a pharmaceutically acceptable salt or solvate thereof;
• (b) glucosamine, a glucosamine derivative or a pharmaceutically acceptable salt or solvate thereof, wherein the glucosamine derivative is selected from glucosamine sulfate, N-acetyl glucosamine, quarternized amino glucosamine, and mixtures thereof;
• (c) L-glycine or a pharmaceutically acceptable salt or solvate thereof;
• and
• (d) vitamin B12, a derivative thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein the Vitamin B12 derivative is selected from cobalamin, methyl cobalamin, hydroxycobalamin, and mixtures thereof,
• wherein the subject is suffering from at least one symptom of the mood disorder and the method eliminates the symptom, reduces the severity of the symptom, or reduces the frequency of occurrence of the symptom.