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AssigneeJulius-Maximilians-UniversitäT WüRzburg
InventorsThomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
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A method for treating or preventing kidney fibrosis, comprising administering to a subject having kidney fibrosis or suspected of having kidney fibrosis a modified oligonucleotide consisting of 17 to 21 linked nucleosides, wherein the nucleobase sequence of the modified oligonucleotide is 100% complementary to the nucleobase sequence of miR-21 (SEQ ID NO:
Dependencies are inferred from the claim text.