Knottin-drug conjugates and methods of using the same
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsNicholas COX, Jennifer R. COCHRAN, Mark SMITH, James R. KINTZING
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Abstract
Provided are knottin-drug conjugates. The conjugates include a knottin peptide that includes an engineered loop that binds to a target on a cancer cell surface, and a drug (e.g., a nucleoside drug) conjugated to the knottin peptide through a linker. Also provided are pharmaceutical compositions and kits that include the knottin-drug conjugates, as well as methods of using the knottin-drug conjugates, e.g., for therapeutic purposes.
Claims32
A knottin-drug conjugate, comprising:
- a knottin peptide comprising an engineered loop that binds to a target on a cancer cell surface;
- and
- a nucleoside drug conjugated to the knottin peptide through a linker.
A method of making a knottin-drug conjugate, comprising:
- conjugating a nucleoside drug to a knottin peptide comprising an engineered loop that binds to a target on a cancer cell surface.
-38. (canceled)
Dependencies are inferred from the claim text.