Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as nad+ increasing precursors

A method for increasing intracellular NAD+ in a subject mammal, comprising

• delivering to the mammal in need of such treatment an effective amount of at least one compound of formula (Ia) or a salt, solvate, or prodrug thereof:
• wherein R6 is selected from the group consisting of hydrogen, —C(O)R′, —C(O)OR′, —C(O)NHR′, substituted or unsubstituted (C1-C8)alkyl, substituted or unsubstituted (C1-C8)cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heterocycle;
• R′ is selected from the group consisting of hydrogen, —(C1-C8)alkyl, —(C1-C8)cycloalkyl, aryl, heteroaryl, heterocycle, aryl(C1-C4)alkyl, and heterocycle(C1-C4)alkyl;
• and
• R7 and R8 are independently selected from the group consisting of hydrogen, —C(O)R′, —C(O)OR′, —C(O)NHR′, substituted or unsubstituted (C1-C8)alkyl, substituted or unsubstituted (C1-C8)cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl(C1-C4)alkyl, and substituted or unsubstituted heterocycle(C1-C4)alkyl;
• provided that R6, R7, and R8 are not all simultaneously hydrogen;
• or
• a compound of formula (IIa), or a salt, solvate, or prodrug thereof:
• wherein R6, R7, and R8 are as defined above for the compounds of formula (Ia) and wherein R1 is selected from hydrogen and (C1-C4)alkyl;
• provided that R1, R6, R7, and R8 are not all simultaneously hydrogen;
• wherein NAD+ biosynthesis is increased.

A method for increasing intracellular NADH in a subject mammal, comprising

• delivering to the mammal in need of such treatment an effective amount of at least one compound of formula (I-Ha) or a salt, solvate, or prodrug thereof:
• wherein R6 is selected from the group consisting of hydrogen, —C(O)R′, —C(O)OR′, —C(O)NHR′, substituted or unsubstituted (C1-C8)alkyl, substituted or unsubstituted (C1-C8)cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heterocycle;
• R′ is selected from the group consisting of hydrogen, —(C1-C8)alkyl, —(C1-C8)cycloalkyl, aryl, heteroaryl, heterocycle, aryl(C1-C4)alkyl, and heterocycle(C1-C4)alkyl;
• and
• R7 and R8 are independently selected from the group consisting of hydrogen, —C(O)R′, —C(O)OR′, —C(O)NHR′, substituted or unsubstituted (C1-C8)alkyl, substituted or unsubstituted (C1-C8)cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycle, substituted or unsubstituted aryl(C1-C4)alkyl, and substituted or unsubstituted heterocycle(C1-C4)alkyl;
• or
• a compound of formula (II-Hc), or a salt, solvate, or prodrug thereof
• wherein R6, R7, and R8 are as defined above for the compounds of formula (I-Ha) and wherein R1 is selected from hydrogen and (C1-C4)alkyl;
• wherein NADH biosynthesis is increased.