Pharmaceutical composition having improved content uniformity
AssigneeIntas Pharmaceuticals Ltd.
InventorsPriyank PATEL, Mayur PATEL, Mahendra PATEL, Balvir SINGH, Ashish SEHGAL
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Abstract
This present invention relates to pharmaceutical compositions comprising cyclophosphamide alone and/or in combination with one or more pharmaceutical active ingredients and one or more pharmaceutically acceptable excipients wherein the cyclophosphamide has D90 particle size less than 100 microns.
Claims12
A pharmaceutical composition comprising cyclophosphamide and one or more pharmaceutically acceptable excipients, wherein cyclophosphamide has D90 particle size less than 100 microns.
A process for the preparation of pharmaceutical composition comprising cyclophosphamide alone and/or in combination with one or more pharmaceutical active ingredient and one or more pharmaceutically acceptable excipients, wherein the cyclophosphamide has D90 particle size less than 100 microns.
A pharmaceutical composition comprising cyclophosphamide and capecitabine in the form of bilayer tablet, wherein the first layer comprises capecitabine and one or more excipients, and the second layer comprises cyclophosphamide and one or more excipients, wherein the cyclophosphamide has D90 particle size less than 100 microns.
A pharmaceutical composition comprising cyclophosphamide and capecitabine in the form bilayer tablet, wherein the first layer comprises capecitabine and one or more excipients, and the second layer comprises cyclophosphamide and one or more excipients, wherein the cyclophosphamide has D90 particle size less than 100 microns;
- wherein the said pharmaceutical composition have a content uniformity between 95% and 105% and acceptance value less than 15 as per USP <905> uniformity of dosage units.
Dependencies are inferred from the claim text.