17a,21-diesters of cortexolone for use in the treatment of tumors
AssigneeCosmo Technologies Limited
InventorMara GERLONI
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Abstract
The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
Claims23
A compound of formula (I):
- wherein:
- R is C(O)—R1;
- R1 is a hydrogen or linear alkyl chain containing 2 to 5 carbon atoms;
- and
- R′ is a linear alkyl chain containing 3 to 6 carbon atoms or an optionally substituted aryl group or an optionally substituted heteroaryl group;
- wherein R1 and R′ are not the same.
5-19. (canceled)
22-33. (canceled)
A method of treating precancerous lesions, dysplasias, metaplasias and tumor diseases in a subject in need thereof, comprising administrating to said subject a therapeutically effective amount of a compound of formula (I):
- wherein:
- R is C(O)—R1;
- R1 is hydrogen or a linear alkyl chain containing 2 to 5 carbon atoms;
- and
- R′ is a linear alkyl chain containing 3 to 6 carbon atoms or an optionally substituted aryl group or an optionally substituted heteroaryl group;
- wherein R1 and R′ are not the same.
36-37. (canceled)
The method of claim 37, wherein the tumor diseases are solid tumors.
A method of treating a disease or disorder mediated by glucocorticoid, in a subject in need thereof, the method comprising administrating to said subject a therapeutically effective amount of a compound of formula (I):
- wherein:
- R is C(O)—R1;
- R1 is hydrogen or a linear alkyl chain containing 2 to 5 carbon atoms;
- and
- R′ is a linear alkyl chain containing 3 to 6 carbon atoms or an optionally substituted aryl group or an optionally substituted heteroaryl group;
- wherein R1 and R′ are not the same.
Dependencies are inferred from the claim text.