Methods and compositions for the inhibition of pin1
AssigneesBeth Israel Deaconess Medical Center, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Serv
InventorsKun Ping LU, Matthew Brian BOXER, Mindy Irene Emily DAVIS, Rajan PRAGANI, Min SHEN, Anton Momtchilov SIMEONOV, Shuo WEI, Xiao Zhen ZHOU
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Abstract
The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
Claims24
A method of inhibiting Pin1 by contacting Pin1 with a Table 1 Compound.
A method of treating an immune disorder in a subject, comprising the step of administering to a subject in need thereof a therapeutically effective amount of a Table 1 Compound.
A method of treating a proliferative disorder comprising the step of administering to a subject in need thereof a therapeutically effective amount of a Table 1 Compound.
A method of treating an immune disorder in a subject, comprising the steps of determining Pin1 marker levels in a sample from said subject;
- and administering a therapeutically effective amount of a Table 1 Compound to said subject if said sample from said subject is determined to have elevated Pin1 marker levels.
A method of treating a proliferative disorder in a subject, comprising the steps of determining Pin1 marker levels in a sample from said subject;
- and administering a therapeutically effective amount of a Table 1 Compound to said subject if said sample from said subject is determined to have elevated Pin1 marker levels.
The method of any of the preceding claims, further comprising the administration of a second therapeutic compound, wherein said second therapeutic compound is an anti-inflammatory compound, anti-microbial compound, anti-viral compound, or an anti-cancer compound.
A pharmaceutical composition comprising a Table 1 Compound.
The pharmaceutical composition of claim 26, wherein said compound is formulated as a pill, ointment, cream, foam, capsule, or a liquid.
Dependencies are inferred from the claim text.