Compositions and Methods for the Delivery of Therapeutics
AssigneeBoard of Regents of the University of Nebraska
InventorsHoward E. Gendelman, Xin-Ming Liu, Benson Edagwa
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Abstract
The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.
Claims33
A nanoparticle comprising at least one nucleoside-analog reverse transcriptase inhibitor prodrug and at least one surfactant,
- wherein said nucleoside-analog reverse transcriptase inhibitor prodrug is a nucleoside-analog reverse transcriptase inhibitor wherein the sugar of the nucleoside-analog reverse transcriptase inhibitor is conjugated with a hydrophobic aliphatic or alkyl.
(canceled)
A nucleoside-analog reverse transcriptase inhibitor prodrug comprising a nucleoside-analog reverse transcriptase inhibitor wherein the sugar of the nucleoside-analog reverse transcriptase inhibitor is conjugated with a hydrophobic aliphatic or alkyl.
The nanoparticle of claim 33, wherein said macrophage targeting ligand is folate.
Dependencies are inferred from the claim text.