Quinazoline derivatives substituted by aniline, preparation method and use thereof

A compound represented by a general formula (I), a pharmaceutically acceptable salt thereof or a stereoisomer thereof:

• wherein
• R1 is selected from the group consisting of the following groups that are unsubstituted or substituted by 1-2 Q1 substituents:
• a 6-10-membered fused ring-C0-6alkyl group, a 7-10-membered spiro ring-C0-6alkyl group or a 7-10-membered bridged ring-C0-6alkyl group, wherein 1-3 carbon atoms of said fused ring, spiro ring or bridged ring can be replaced with 1-3 hetero atoms and/or groups that can be identical or different and are selected from the group consisting of O, S(O)m, N(H)m, NCH3 and C(O), provided that after the replacement, O and C(O) in the ring are not adjacent to each other,
• Q1 is selected from the group consisting of halogen, hydroxyl, amino, carboxyl, cyano, a C1-16alkyl group, a C1-6alkoxyl group, a C1-6alkylamino group, a di(C1-6alkyl)amino group, a C1-6alkylcarbonyloxy group, a C1-6alkylacylamino group, a C1-6alkylsulfonyl group, a C1-6alkylsulfinyl group, a C1-6alkylsulfonylamino group and a C3-8cycloalkyl group;
• R2 is selected from the group consisting of hydrogen, a C1-6alkyl group or a C1-6alkoxyl group that is unsubstituted or substituted by 1-2 Q2 substituents, a formyl group that is substituted by a Q2 substituent or N(H)m,
• Q2 is selected from the group consisting of halogen, hydroxyl, amino, carboxyl, cyano, a C1-16alkyl group, a C1-6alkoxyl group, a C1-6alkylamino group, a di(C1-6alkyl)amino group, a C1-6alkylcarbonyloxy group, a C1-6alkylacylamino group, a C1-6alkylsulfonyl group, a C1-6alkylsulfinyl group, a C1-6alkylsulfonylamino group, a C3-8cycloalkyl group, an unsaturated C5-7 cyclic hydrocarbyl and a saturated or unsaturated 3-8-membered heterocyclyl, wherein the C3-8cycloalkyl, the unsaturated C5-7 cyclic hydrocarbyl and the saturated or unsaturated 3-8-membered heterocyclyl can further substituted by 1-2 Q3 substituents,
• Q3 is selected from the group consisting of halogen, hydroxyl, amino, carboxyl, cyano, a C1-16alkyl group, a C1-6alkoxyl group, a C1-6alkylamino group, a di(C1-6alkyl)amino group, a C1-6alkylcarbonyloxy group, a C1-6alkylacylamino group, a C1-6alkylsulfonyl group, a C1-6alkylsulfinyl group, a C1-6alkylsulfonylamino group and a halogen-substituted C1-6alkoxy group;
• R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, a C1-6alkyl group, a C1-6alkoxyl group, a C1-6alkyl group or a C1-6alkoxyl group that is substituted by halogen, a C1-6alkylcarbonyloxy group, a C1-6alkylacylamino group, a C1-6alkylsulfonyl group, a C1-6alkylsulfinyl group or a C1-6alkylsulfonylamino group;
• R4, R5 and R6 are each independently selected from the group consisting of hydrogen, halogen, a C1-6alkyl group, a C1-6alkoxyl group, a C1-6alkyl group or a C1-6alkoxyl group that is substituted by halogen, a C1-6alkylamino group or a di(C1-6alkyl)amino group;
• L is selected from the group consisting of a covalent bond, O, S(O)m, N(H)m, NCH3 or C(O);
• n is 1, 2 or 3;
• and
• m is 0, 1 or 2.