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US 2017/0304304 A1Published application
Therapeutic compounds
AssigneeUniversity of Iowa Research Foundation
InventorLeonard R. MacGillivray
Life of this patent
Estimating the term…
Abstract
The invention provides a compound of formula I: wherein X, Y, Z have any of the values defined in the specification or a salt thereof. The compound is useful as anti-cancer agents. The invention also provides processes and intermediates disclosed herein that are useful for preparing a compound of formula I or a salt thereof.
Claims14
A compound of formula I:
- or a salt thereof;
- wherein each X is independently selected from the group consisting of —N═, —CH═ and
- with the proviso that no more than two of X can be —N═;
- each Y is independently selected from the group consisting of —N═, —CH═ and
- with the proviso that no more than two of Y can be —N═;
- Z is halogen;
- each R1 and R2 is independently selected from the group consisting of halo, hydroxy, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, hydroxy(C1-C4)alkyl, —NO2, —N(Ra)2, —CN, —C(O)—N(Ra)2, —O—Ra, —S—Ra, —O—C(O)—Ra, —C(O)—Ra, —C(O)—ORa, —N(Ra)—C(O)—Ra and —N(Ra)—C(O)—N(Ra)2;
- and
- each Ra is independently hydrogen or (C1-C4)alkyl.
6 more elements
Dependencies are inferred from the claim text.