Oxazoline and isoxazoline derivatives as crac modulators

A compound of Formula (I):

• wherein,
• ring E is a 5-membered non aromatic heterocyclic ring selected from
• X, at each occurrence, is independently selected from —C(O)—, —CR4R5— and —NR—;
• Y, at each occurrence, is independently selected from —C(O)— and —CR4R5—;
• R is selected from alkyl, haloalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, —C(O)NR6R7, —C(O)OR6 and —C(O)R6;
• ring W is selected from aryl, heteroaryl, cycloalkyl and_heterocyclyl;
• R1, which may be same or different at each occurrence, is independently selected from halo, cyano, nitro, hydroxyl, alkyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, aryl, heteroaryl, heterocyclyl, —S(O)nR6, —NR6S(O)2R7, —NR6(CR8R9)nC(O)OR6, —NR6(CR8R9)nC(O)R6, —NR6(CR8R9)nC(O)NR6R7, —C(O)NR6R7, —C(O)(O)R6, —C(O)R6, —OC(O)R6, and 'OC(O)NR6R7;
• R2, which may be same or different at each occurrence, is independently selected from hydrogen, halo, hydroxyl, cyano, nitro, alkyl, haloalkyl, alkenyl, alkynyl, alkoxy, haloalkoxy, alkenyloxy, alkynyloxy, cycloalkyl, cycloalkoxy, —C(O)OR6, —NR6R7, —C(O)R6, —NHS(O)2R7 and —NHC(O)R6;
• R3, which may be same or different at each occurrence, is independently selected from hydrogen, halo, hydroxyl, alkyl, alkoxy, haloalkyl, haloalkoxy, —NR6R7, —NR6S(O)2R7, C(O)NR6R7 and —C(O)OR6;
• R4 and R5, which may be same or different at each occurrence, are independently selected from hydrogen, halo, —OR10, alkyl, haloalkyl, hydroxyalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, —(CR8R9)nC(O)NR6R7, —C(O)R6 , and —(CR8R9)nC(O)OR6;
• provided that, when any of R4 or R5 in Y is —OR10 then R10 is not hydrogen;
• or
• R4 and R5, taken together with the carbon atom to which they are attached to, may form a substituted or unsubstituted 3- to 7-membered carbocyclic or heterocyclic ring;
• or
• any one of R4 and R5 in X and any one of R4 and R5 in Y combined together, when they are attached to carbon atoms, may form a 4- to 7-membered substituted or unsubstituted heterocyclic ring in order to give a bicyclic heterocyclic ring;
• provided that
• both of X and Y are not simultaneously —C(O)—;
• ring D is selected from
• wherein A1 and A2 are independently selected from C and N;
• G is selected from S, NR12 and O;
• L is —C(O)NR11— or —NR11C(O)—;
• R11, at each occurrence, is independently selected from hydrogen, alkyl and aryl;
• R12 is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl;
• R10 is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl;
• R6 and R7, which may be same or different at each occurrence, are independently selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl;
• or R6 and R7, taken together with the nitrogen atom to which they are attached to, may form a substituted or unsubstituted 3- to 14-membered heterocyclic ring;
• R8 and R9, which may be same or different at each occurrence, are independently selected from hydrogen, halo, alkyl and alkoxy;
• or R8 and R9, taken together with the carbon atom they are attached to, may form a 3- to 6-membered cyclic ring wherein the cyclic ring may be carbocyclic or heterocyclic;
• n is an integer ranging from 0 to 2, both inclusive;
• p is an integer ranging from 0 to 5, both inclusive;
• q is an integer ranging from 1 to 4, both inclusive;
• and
• wherein alkyl, haloalkyl, hydroxyalkyl, alkenyl, alkynyl, alkoxy, haloalkoxy, alkenyloxy, alkynyloxy, cycloalkyl, cycloalkoxy, aryl, heteroaryl, heterocyclyl, wherever they occur may optionally be substituted with one or more substituents independently selected from hydroxy, halo, cyano, nitro, oxo (═O), thio (═S), alkyl, haloalkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, heteroaryl, heterocyclic ring, heterocyclylalkyl, heteroarylalkyl, —C(O)ORx, —C(O)Rx, —C(S)Rx, —C(O)NRxRy, —NRxC(O)NRyRz, —N(Rx)S(O)Ry, —N(Rx)S(O)2Ry, —NRxRy, —NRxC(O)Ry, —NRxC(S)Ry, —NRxC(S)NRyRz, —S(O)2NRxRy, —ORx, —OC(O)Rx, —OC(O)NRxRy, —RxC(O)ORy, —RxC(O)NRyRz, —RxC(O)Ry, —SRx, and —S(O)2Rx;
• wherein each occurrence of Rx, Ry and Rz are independently selected from hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclic ring, heterocyclylalkyl ring and heteroarylalkyl;
• or a pharmaceutically acceptable salt thereof or streoisomers thereof.