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US 2017/0304294 A1Published application
Use of nalmefene in non-alcoholic steatohepatitis
AssigneeTaiwanj Pharmaceuticals Co., Ltd.
InventorsEdwin SC WU, Peter J.S. CHIU, May Mei-chi HSU
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Abstract
The present invention relates to new medical uses of morphinans such as nalmefene and naltrexone and their related derivatives, pharmaceutical formulations thereof, and use thereof for prevention and treatment of NASH, NAFLD, and/or ASH.
Claims11
A method of prophylaxis or treating NAFLD, NASH, or ASH, which comprises administering to a human or animal in need thereof a therapeutic amount of a compound of the formula (I), wherein:
- A is OH or OCH3. R is H, CH3, or cyclopropylmethy;
- X is the oxygen atom, Y is CH2 or oxygen, Z is H or OH, said compounds being administered as a racemic mixture or as enantiomers, diastereoisomers, or pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.