Coordinated metabolic reprogramming in response to productive viral infections
AssigneeSt. Jude Children's Research Hospital
InventorsHeather S. Smallwood, Marie Morfouace, Martine F. Roussel, Paul G. Thomas
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Abstract
The invention generally relates to methods of treating viral infections using known drugs and pharmaceutical compositions comprising same. More specifically, the disclosed methods are useful for the treatment of viral infections that are enveloped viruses. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims20
A method for treating viral infection, the method comprising the step of administering to the subject an effective amount of at least one compound having a structure selected from:
- or a pharmaceutically acceptable salt thereof, thereby treating the subject for viral infection.
A pharmaceutical composition comprising an effective amount of at least one compound having a structure selected from:
- or a pharmaceutically acceptable salt thereof;
- and an effective amount of:
- (a) at least one antiviral agent or a pharmaceutically acceptable salt thereof;
- or
- (b) at least one agent known to weaken the immune system or a pharmaceutically acceptable salt thereof;
- and
- a pharmaceutically acceptable carrier.
A kit comprising an effective amount of at least one compound having a structure selected from:
- or a pharmaceutically acceptable salt thereof, and one or more of:
- (a) at least one antiviral agent;
- (b) at least one agent known to treat an autoimmune disorder;
- (c) instructions for treating a viral infection;
- (d) instructions for treating the autoimmune disorder;
- (e) instructions for administering the at least one compound in connection with treating a viral infection;
- or
- (f) instructions for administering the at least one compound in connection with reducing the risk of viral infection.
Dependencies are inferred from the claim text.