Tetrahydroisoquinoline Derivatives

A compound of formula (I), or a pharmaceutically acceptable salt thereof,

• wherein
• R1 is hydrogen, halogen, cyano or hydroxy;
• C1-6 alkyl, C1-6 alkoxy, C1-6 alkylsulfanyl, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl or (C1-6-alkylsulfonyl)amino, any of which groups is optionally substituted by one or more substituents;
• R2 is hydrogen, cyano, or halogen;
• or C1-6 alkyl, C1-6 alkoxy, C1-6 alkylsulfanyl, C1-6 alkylsulfinyl, C1-6 alkyl sulfonyl, C1-6 alkylsulfonylamino, (C1-6 alkyl sulfonyl)amino(C1-6 alkyl), C1-6 alkylamido, (C1-6 alkylacyl)amino, (C1-6 alkylacyl)amino(C1-6 alkyl), or heteroaryl, any of which groups is optionally substituted by one or more substituents;
• or
• R1 and R2 are linked together to form with the adjacent aromatic group a heterocycle of formula (i):
• wherein R2b is hydrogen or C1-6 alkylsulfonyl;
• R3 is halogen, C1-6 alkyl, C1-6 alkoxy or cyano;
• R4 is hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyloxy or C1-6 alkylaminocarbonyloxy;
• R4′ is hydrogen, halogen or C1-6 alkyl;
• or R4 and R4′ together form an oxo group;
• R5 is hydrogen, cyano or hydroxy;
• or C1-6 alkyl;
• C1-6-alkylsulfonyl, C1-6-alkylsulfonylamino;
• C1-6-alkylsulfonylamino(C1-6 alkyl), heterocycle, C1-6 alkylacylamino(C1-6 alkyl), C1-6 alkylureido(C1-6 alkyl), C1-6alkylcarbamate(C1-6 alkyl);
• amido;
• C1-6alkoxycarbonyloxy(C1-6alkyl);
• amino group;
• N-cyano-S—(C1-6-alkyl)sulfonimidoyl, N,S-(di-C1-6-alkyl)sulfonimidoyl, aminosulfinyl;
• C1-6-alkylsulfinyl;
• aminosulfonyl;
• (di-C1-6-alkyl)(oxido)-λ6-sulfanylidene-amino, amino(C1-6 alkyl), or amido(C1-6 alkyl);
• any of which groups is optionally substituted by one or more substituents;
• R6 is hydrogen;
• R7 is hydrogen or (C1-6alkylsulfonyl)amino;
• X is CR9 or N;
• wherein R9 is hydrogen, halogen or C1-6-alkyl substituted by hydroxy;
• Z is CH or N;
• and
• Y is CH2 or NH.