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US 2017/0304288 A1Published application
Formulations of Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases
AssigneeTexas Southern University
InventorsOmonike A. Olaleye, Jun O. Liu
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Abstract
Provided herein are formulations and co-solvent formulations and methods for treating an infectious disease utilizing the same. The formulations and co-solvent formulations may comprise a hydroxyquinoline analog or its pharmaceutically acceptable salt, a solvent and at least two surfactants. Also provided are methods of quantitating a hydroxyquinoline analog in a sample via chromatographic/spectrometric measurements.
Claims30
A formulation comprising:
- a hydroxyquinoline analog having a chemical structure
- wherein R1 is a halogen;
- and
- R2 and R3 independently are halogen, OH or —OC(O)CH3, or R2 and R3 together form an N-substituted 1,3-oxazinanane;
- or
- a pharmaceutically acceptable salt thereof;
- a solvent, a co-solvent or a combination thereof;
- and
- a surfactant.
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A method for quantifying a hydroxyquinoline analog in a sample, comprising:
- obtaining the sample;
- eluting, via chromatography, the hydroxyquinoline analog in the sample and an internal standard;
- measuring, via spectrometry, a peak area of the hydroxyquinoline analog and a peak area of the internal standard eluted from the sample;
- calculating a ratio of the peak area of the hydroxyquinoline analog to the peak area of the internal standard;
- and
- correlating the sample peak area ratio to a known concentration of the hydroxyquinoline analog on a standard curve, thereby quantifying the hydroxyquinoline analog in the sample.
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A co-solvent formulation, comprising:
- a hydroxyquinoline analog having a chemical structure
- or a pharmaceutically acceptable salt thereof;
- a co-solvent;
- and
- at least 2 surfactants.
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Dependencies are inferred from the claim text.