Therapeutic inhibitor for EBV-associated tumor with tailor responsive optical imaging
AssigneeHong Kong Baptist University
InventorsKa Leung WONG, Nai Ki MAK, Lijun JIANG
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Abstract
This invention provides a nucleus-permeable small-molecule inhibitor, L2P4 (where L2 is 4-(4-(Diethylamino)styryl)-N-carboxymethylpyridinium chloride and P4 is an amino acid sequence comprising CAhxYFMVFGGRrRK and they were coupled through amide bond) and synthesis thereof, which effectively targets the dimerization interface of EBNA1, a critical process for the growth of EBVs and the associated tumors. The present invention also provides method of treating and imaging EBV-associated cancers.
Claims12
A nucleus-permeable small-molecule inhibitor comprising 4-(4-(Diethylamino)styryl)-N-carboxymethylpyridinium chloride coupled to an amino acid sequence comprising CAhxYFMVFGGRrRK (SEQ ID NO. 3) through an amide bond.
Dependencies are inferred from the claim text.