Compounds and compounds for use in methods for treating diseases or conditions mediated by protein disulfide isomerase

A method for inhibiting protein disulfide isomerase in a patient, comprising administering to the patient a compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient or solvent, wherein:
• R1 is OH or acyloxy;
• R2 is selected from H, lower alkyl, and halogen;
• R3 and R4 are independently selected from H, F, and alkyl, or R3 and R4 taken together with the carbon atom to which they are attached form a carbonyl group or a substituted or unsubstituted 3-7 membered cycloalkyl ring;
• R5 is OR7, or NR7R8, wherein R7 and R8 are each independently selected from H and substituted or unsubstituted alkyl, aryl, aralkyl, cycloalkyl, and cycloalkyl alkyl, or taken together with the nitrogen atom to which they are attached form a substituted or unsubstituted 3-7 membered heterocyclyl ring;
• W represents a C1-C3 alkylene group;
• X is selected from O, S, and NR9, wherein R9 is H or lower alkyl;
• and
• R6 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl.

A method for inhibiting protein disulfide isomerase in a cell, comprising contacting the cell with a compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient or solvent, wherein:
• R1 is OH or acyloxy;
• R2 is selected from H, lower alkyl, and halogen;
• R3 and R4 are independently selected from H, F, and alkyl, or R3 and R4 taken together with the carbon atom to which they are attached form a carbonyl group or a substituted or unsubstituted 3-7 membered cycloalkyl ring;
• R5 is OR7, or NR7R8, wherein R7 and R8 are each independently selected from H and substituted or unsubstituted alkyl, aryl, aralkyl, cycloalkyl, and cycloalkyl alkyl, or taken together with the nitrogen atom to which they are attached form a substituted or unsubstituted 3-7 membered heterocyclyl ring;
• W represents a C1-C3 alkylene group;
• X is selected from O, S, and NR9, wherein R9 is selected from H or lower alkyl;
• and
• R6 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl.