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US 2017/0304279 A1Published application
Phosphoinositide 3-kinase inhibitor with a zinc binding moiety
AssigneeCuris, Inc.
InventorsXiong Cai, Haixiao Zhai, Chengjung Lai, Chenggeng Qian
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Abstract
The invention provides a compound of Formula I, Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.
Claims10
1-20. (canceled)
A method of producing Compound 1,
- comprising the step of reacting Compound 108,
- wherein R is methyl or ethyl, with hydroxylamine, thereby producing Compound 1.
A compound of the formula
- wherein R is ethyl or methyl.
Dependencies are inferred from the claim text.