An inhalable rapamycin formulation for the treatment of pulmonary hypertension
AssigneeLAM Therapeutics, Inc.
InventorsThomas Armer, Lawrence S. Melvin, Jr., Jonathan M. Rothberg, Henri Lichenstein
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Abstract
The present invention relates to methods and compositions for the treatment and prophylaxis of pulmonary arterial hypertension (PAH) in a human subject in need of such treatment, the methods comprising the pulmonary administration to the subject, preferably via inhalation of a composition comprising rapamycin or a prodrug or derivative thereof.
Claims51
A pharmaceutical aerosol composition in the form of a dry powder for pulmonary delivery comprising an amount of microparticles of a rapamycin composition, particles of a carrier, and one or more optional excipients, for use in the treatment and prophylaxis of pulmonary arterial hypertension (PAH) in a human subject in need of such therapy or treatment, wherein the formulation is effective to deliver a therapeutic amount of the rapamycin composition to the lungs.
Dependencies are inferred from the claim text.