Isoxazole derivatives as fxr agonists and methods of use thereof

A compound represented by Formula I, or a pharmaceutically acceptable salt thereof:

• wherein,
• R1 is hydrogen, halogen, cyano, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl or optionally substituted 3- to 6-membered heterocycloalkyl;
• R2 is an optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, or optionally substituted C3-C8 cycloalkyl;
• is selected from the group consisting of;
• n is 0 or 1;
• is phenyl or a 5- or 6-membered heterocyclic or heteroaryl containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein said phenyl, heterocycle or heteroaryl is optionally substituted with one or two substituents independently selected from substituted or unsubstituted —C1-C8 alkyl, halo, and haloalkyl,
• R3 is:
• R4 and R5 are independently selected from the group consisting of:
• 1) Hydrogen;
• 2) Optionally substituted —C1-C8 alkyl;
• 3) Optionally substituted —C2-C8 alkenyl;
• 4) Optionally substituted —C2-C8 alkynyl;
• and
• 5) Optionally substituted —C3-C8 cycloalkyl;
• R6 is selected from the group consisting of:
• 1) Optionally substituted —C1-C8 alkyl;
• 2) Optionally substituted —C2-C8 alkenyl;
• 3) Optionally substituted —C2-C8 alkynyl;
• 4) Optionally substituted —C3-C8 cycloalkyl;
• 5) Optionally substituted aryl;
• 6) Optionally substituted arylalkyl;
• 7) Optionally substituted heterocycloalkyl;
• 8) Optionally substituted heteroaryl;
• 9) Optionally substituted heteroarylalkyl;
• and
• 10) NR7R8;
• wherein, R7 and R8 are each independently selected from hydrogen, optionally substituted —C1-C8 alkyl, optionally substituted —C2-C8 alkenyl, optionally substituted —C2-C8 alkynyl, optionally substituted —C3-C8 cycloalkyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted 3- to 8-membered heterocycloalkyl, optionally substituted heteroaryl, optionally substituted alkylheteroaryl, or R7 and R8 are taken together with the nitrogen atom which they are attached to form an optionally substituted heterocyclic ring.