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AssigneesMerck Sharp & Dohme Corp., Pfizer Inc.
InventorsRamachandra G. Naik, Elizabeth S. Ommen, James Michael Rusnak, Steven G. Terra
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The present invention relates to certain SGLT-2 inhibitors, such as ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof, for treating and/or preventing metabolic disorders, such as type 1 or type 2 diabetes mellitus or pre-diabetes, in patients with renal impairment or chronic kidney disease (CKD). The present invention also relates to methods for preventing neuronal damage following the incidence of ischemic stroke and close-head traumatic brain injury in animals comprising the step of administering to an animal, in need of such treatment, a therapeutically effective amount of ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof.
A method of treating prediabetes, type 1 or type 2 diabetes mellitus in a patient in need thereof comprising administering ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof to the patient, wherein the patient has moderate renal impairment or stage 3 chronic kidney disease (CKD).
A method for improving glycemic control in a patient with type 2 diabetes comprising administering ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof to the patient, wherein the patient has moderate renal impairment or stage 3 chronic kidney disease (CKD).
A method of treating prediabetes, type 1 or type 2 diabetes comprising:
11-15. (canceled)
(canceled)
Dependencies are inferred from the claim text.