Silvestrol, silvestrol analogs and uses thereof
AssigneeOhio State Innovation Foundation
InventorsRobert A. Baiocchi, John Thomas Patton, David M. Lucas, Douglas Kinghorn, Michael Grever
Life of this patent
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Abstract
Disclosed herein are treatment methods, vaccination methods, compositions, co-therapeutic methods, combination therapeutic compositions and kits comprising silvestrol and silvestrol analogs alone or in combination with therapeutic and preventative therapies. Disclosed herein are also methods, compositions and kits that can be used to treat cancer, viral infections, to modulate the immune system or as preventative therapies.
Claims21
1-128. (canceled)
A composition comprising:
- silvestrol or a silvestrol analog;
- a vaccine;
- and a pharmaceutically acceptable carrier.
A method of vaccinating a subject against cancer, comprising administering to a subject not yet diagnosed with cancer a composition comprising:
- a) silvestrol or silvestrol analog;
- and
- b) a vaccine.
A cancer treatment method comprising administering to a patient diagnosed with cancer a composition comprising:
- a) silvestrol or silvestrol analog;
- and
- b) a vaccine;
- wherein the composition is administered in an amount effective to treat the cancer, and
- wherein the cancer comprises EBV-driven lymphoma, EBV+ lymphomas, nasopharngeal carcinoma, aggressive hematologic malignancies, Hodgkin's lymphomas, Burkitt's lymphoma, or diffuse large B cell lymphoma.
Dependencies are inferred from the claim text.