Solid pharmaceutical preparation containing levothyroxine
AssigneeMerck Patent GmbH
InventorsHiltrud LINDENBLATT, Thomas T. FRANK, Reiner VONDERSCHMITT
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Abstract
The invention relates to a solid pharmaceutical preparation comprising levothyroxine sodium, gelatine, citric acid and a filler. The solid pharmaceutical preparation has an improved stability.
Claims18
Solid pharmaceutical preparation comprising levothyroxine sodium, gelatine, citric acid and a filler.
, characterized in that citric acid and, if present, the antioxidant is dissolved in the aqueous gelatine solution used in step (a) or is admixed with the granules in step (d).
Process for the production of a solid pharmaceutical preparation according to
A process for the stabilization of levothyroxine sodium, comprising adding to said levothyroxine sodium a stabilizing-effective amount of gelatine, citric acid and a filler.
Dependencies are inferred from the claim text.