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US 2017/0304239 A1Published application
Inhibitors of human immunodeficiency virus replication
AssigneeViiV HEALTHCARE UK (NO.5) LIMITED
InventorsMakonen BELEMA, John A. BENDER, Brett BENO, Robert G. GENTLES, Guo LI, Nicholas A. MEANWELL, Annapurna PENDRI, Zhong YANG, Shirong ZHU
Life of this patent
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Abstract
Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
Claims20
A compound of Formula I, including pharmaceutically acceptable salts thereof:
- wherein:
- R is selected from the group of alkyl, alkenyl, alkoxy, alkylthioxy, C5-C8 bicycloalkyl, C3-C7 cycloalkyl, aryl, and 5-6 member heteroaryl;
- and is substituted with 0-3 substituents selected from the group of alkyl, alkenyloxy, alkoxycarbonyl, alkylcarbonylamino, aminocarbonyl, aryl, benzyloxy, cyano, cycloalkoxy, cycloalkyl, halo, haloalkyl, haloalkoxy, hydroxy and (morpholinyl)sulfonyl
- R1 is selected from the group of alkyl, cycloalkyl, (cycloalkyl)alkyl, aryl, and 5-6 member heteroaryl;
- and is substituted with 0-3 substituents selected from the group of alkyl, alkoxy, alkoxycarbonyl, aryl, cyano, cycloalkyl, halo, haloalkoxy, haloalkyl, 5-6 member heteroaryl, nitro, and N—R2R3, where R2 and R3 are each independently selected from H, alkyl, and cycloalkyl, or R2 and R3 together form heterocycles comprised of 1-3 rings;
- A is a five or six-member heteroaryl ring optionally substituted with alkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, cycloalkyl, halo and haloalkyl;
- and
- B is selected from the group of alkyl, aryl, arylalkyl, C3-C9 cycloalkyl, and 5-6 member heteroaryl, and is substituted with 0-3 substituents selected from the group of alkyl, alkylsulphonyl, alkoxy, alkylaryl, allyloxy, arylalkoxy, cycloalkoxy, cycloalkyl, halo, haloalkoxy, heteroarylcycloalkyl amido, hydroxymethyl, nitro, —CN, —COOR2, —NR2R3, —N(R2)COOR3, —CONR2R3, NH—CO-alkyl, and morpholinyl.
5 more elements
A compound, including pharmaceutically acceptable salts thereof, which is selected from the group of:
A compound, including pharmaceutically acceptable salts thereof, which is selected from the group of:
Dependencies are inferred from the claim text.