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US 2017/0304222 A1Published application
Compounds, Compositions and Methods for Treating Oxidative DNA Damage Disorders
AssigneeIndiana University Research and Technology Corporation
InventorsMark R. KELLEY, Michael R. VASKO
Life of this patent
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Abstract
Compounds, compositions, and formulations, and accompanying methods useful for treating disorders arising from oxidative DNA damage, including oxidative DNA damage resulting from ionizing radiation or other therapy are described herein.
Claims13
-48. (canceled)
A method for treating cancer in a host animal, the method comprising
- a) administering to the host animal ionizing radiation and b) administering to the host animal a therapeutically effective amount of a compound of the formula (I)
- or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof comprising one or more carriers, diluents, or excipients, or a combination thereof, wherein:
- RA represents two substituents each independently hydrogen or alkoxy, where RA are not both hydrogen;
- or
- RA represents a fused aryl ring that is optionally substituted;
- R is selected from the group consisting of hydrogen, halo, alkyl, heteroalkyl cycloalkyl, cycloheteroalkyl, alkoxy, heteroalkoxy cycloalkoxy, cycloheteroalkoxy, alkylthio, heteroalkylthio cycloalkylthio, and cycloheteroalkylthio, each of which is optionally substituted;
- X is selected from the group consisting of alkylene, alkenylene, and alkynylene, each of which is optionally substituted;
- and
- Y forms a carboxylic acid, ester, or amide.
6 more elements
A method for treating cancer in a host animal, the method comprising a) administering to the host animal ionizing radiation and b) administering to the host animal a therapeutically effective amount of a compound of the formula
- or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof comprising one or more carriers, diluents, or excipients, or a combination thereof.
Dependencies are inferred from the claim text.