Manufacture of a pharmaceutical product

A method for the manufacture of a pharmaceutical product comprising more than one pharmacologically active ingredient, comprising:

• i) dispersing a first pharmacologically active ingredient in a first fluid;
• ii) dispersing a second pharmacologically active ingredient and an excipient or carrier in a second fluid;
• iii) mixing said first and second fluids with a carrier fluid to form a multiple emulsion;
• and
• iv) crystallizing the emulsion by heating to form spherical agglomerates.