Programmed cargo release using nucleic acid-stabilized micelles
AssigneeAlbert Einstein College of Medicine
InventorsSamantha E. Wilner, Matthew Levy
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Abstract
Methods and compositions for serum-stabilizing micelles for drug delivery or imaging agent delivery are provided, as well as methods and compositions to enhance micelle-mediated drug delivery. This invention provides a process for synthesizing a lipid micelle comprising one or more lipid-oligonucleotide conjugate molecules, the process comprising contacting an amount of lipid molecules with an amount of lipid-oligonucleotide conjugate molecules sufficient to create a lipid micelle comprising lipid-oligonucleotide conjugate molecules.
Claims30
A process for synthesizing a lipid micelle comprising one or more lipid-oligonucleotide conjugate molecules, the process comprising contacting an amount of lipid molecules with an amount of lipid-oligonucleotide conjugate molecules sufficient to create a lipid micelle comprising lipid-oligonucleotide conjugate molecules.
A composition comprising a lipid micelle comprising one or more lipid-oligonucleotide conjugate molecules, wherein the micelle contains a predetermined drug or imaging molecule, and wherein a first portion of the oligonucleotide of the lipid-oligonucleotide conjugate molecules is capable of forming parallel G-quadruplex with other oligonucleotides of the same sequence.
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Dependencies are inferred from the claim text.