Biodegradable stent
AssigneeTerumo Kabushiki Kaisha
InventorsTakashi KUMAZAWA, Haruhiko KAMIJO, Hiroaki NAGURA
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Abstract
A biodegradable stent that is degraded in a living body includes a stent body that is made of a biodegradable material and is deformed to have an expanded diameter in the living body; and a biodegradable drug-coating portion formed on the stent body. The drug-coating portion is degraded, in an expansion retention period during which an expansion retention force (radial force) of the deformed diameter-expanded stent body that acts on an inner wall of a lumen thereof is maintained, and before 60% of a degradation period from indwelling of the stent body in the living body to complete degradation thereof elapses.
Claims19
A biodegradable stent that is degraded in a living body, the biodegradable stent comprising:
- a stent body that is made of a biodegradable material and is deformed to have an expanded diameter in the living body;
- and
- a biodegradable drug-coating portion formed on the stent body,
- wherein the drug-coating portion is degraded, in an expansion retention period during which an expansion retention force of the deformed diameter-expanded stent body that acts on an inner wall of a lumen thereof is maintained, and before 60% of a degradation period from indwelling of the stent body in the living body to complete degradation thereof elapses.
A biodegradable stent that is degraded in a living body, the biodegradable stent comprising:
- a stent body that is made of a biodegradable material and is deformed to have an expanded diameter in the living body;
- and
- a biodegradable drug-coating portion formed on the stent body,
- wherein the stent body and the drug-coating portion are independent from each other, and contain a polymer selected from the group consisting of aliphatic polyester, polyester, polyanhydride, polyorthoester, polycarbonate, polyphosphazene, polyphosphate ester, polyvinyl alcohol, polypeptide, polysaccharide, proteins, and cellulose, and at least one of biodegradable (co)polymers selected from the group consisting of copolymers that consist of one or more monomers of which the polymers consist, and
- wherein the drug-coating portion contains a biodegradable (co)polymer having a biodegradation rate at which 10% by mass or less of an amount of the (co)polymer remains in the drug-coating portion when the expansion retention force is 0.2 N/mm after the stent is immersed in a phosphate buffered physiological salt solution having a temperature of 37° C., with respect to an amount of the (co)polymer in the drug-coating portion before the immersion.
Dependencies are inferred from the claim text.