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US 2017/0304055 A1Published application
Cohesive bone composition
AssigneeVivex Biomedical, Inc.
InventorsWendy W. Weston, Edgar S. Maldonado, Silvia Daniela Gonzales, Shabnam Namin
Life of this patent
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Abstract
A cohesive bone composition is made from a moldable bone composition intermixed with a bone gel composition. The cohesive bone composition is made from human cadaver bone. A fluid can be added, the fluid may also be laden with cells.
Claims21
A cohesive bone composition comprises:
- a moldable bone composition mixed with a bone gel composition;
- the moldable bone composition consisting of a mixture of cortical bone and cancellous bone, the cortical bone is formed in three portions, a mineralized shaving portion and a demineralized shaving portion and a mineralized powder portion, the cancellous bone is formed in a mineralized crushed cancellous portion, the portions are freeze-dried and mixed together to form a freeze-dried bone composition and when subjected to a fluid, the composition can be molded to a desired shape;
- the bone gel composition consisting of cortical bone consists of cortical bone made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried, wherein a volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being twice the volume of the particles, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is placed in jars for later use;
- and
- wherein a volume of moldable bone composition is mixed with a volume of the bone gel composition and wetted with a fluid to form the cohesive bone composition.
2 more elements
A method of manufacturing a cohesive bone composition of a mixture of a moldable bone composition and a bone gel composition comprises the steps of:
- wherein the method of manufacturing a moldable bone composition comprises the steps of:
- cutting cortical bone plates into long pieces;
- shaving the cortical bone plates to form cortical strands or shavings 3 mm or greater in length;
- demineralizing a first portion of the cortical shavings;
- grinding another portion of the cortical shavings;
- resulting in cortical bone having three portions, a demineralized cortical shavings portion, a mineralized cortical shavings portion and a powered cortical portion;
- cutting and grinding cancellous bone to form a portion of mineralized crushed cancellous bone from a size of 1000 to 1700 microns;
- freeze-drying each portion;
- mixing together all of the portions in a predetermined ratio to form a freeze-dried composition;
- and
- wherein the method of making a bone gel composition consisting of cortical bone comprises the steps of:
- preparing cortical bone by cutting the cortical bone into pieces, freeze-drying the pieces and then grinding into particles and demineralizing the ground particles and the freeze-drying the demineralized ground particles to form DBM particles;
- autoclaving a volume of the DBM particles mixed with sterile water in a 2:1 ratio by volume for a predetermined time at a pre-set temperature and pressure to form a gelatin;
- cooling the gelatin to form a bone gel composition;
- packaging the resulting bone gel composition;
- and
- wherein a volume of moldable bone composition is mixed with a volume of the bone gel composition and wetted with a fluid to form the cohesive bone composition.
14 more elements
Dependencies are inferred from the claim text.