System and method for noninvasive analysis of subcutaneous tissue

A system for noninvasive analysis of tissue, the system comprising:

• at least one source of infrared radiation to irradiate the tissue, the infrared radiation including radiation in a first spectral band that is strongly absorbed by water, and including radiation in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical;
• at least one radiation detector to measure an intensity of radiation in each of the two spectral bands that emerges from the tissue;
• and
• a processor that is configured to calculate a relative absorption by the tissue of radiation in one of spectral bands relative to absorption by the tissue of radiation in the other of the spectral bands and determine concentration of Propofol in accordance with the calculated relative absorption,
• wherein the interaction of the radiation comprises at least one of absorption and scattering.

A device for noninvasive analysis of tissue, the device comprising:

• a base, removably attachable to skin tissue;
• a clipping element, removably attachable to the base;
• a transceiver portion, coupled to the clipping element and comprising:
• at least one source of infrared radiation to irradiate the tissue;
• at least one radiation detector to measure an intensity of radiation that emerges from the tissue;
• and
• a processor that is configured to calculate a relative absorption by the tissue of radiation in a first spectral band relative to absorption by the tissue of radiation in a second spectral band, and determine concentration of Propofol in accordance with the calculated relative absorption,
• wherein the interaction of the radiation comprises at least one of absorption and scattering, and wherein the clipping element is configured to move the transceiver portion relative to the base in at least one direction.