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US 2017/0299601 A1Published application
Ratiometric and multiplexed sensors from single chirality carbon nanotubes
AssigneeMassachusetts Institute of Technology
InventorsJuan Pablo Giraldo Gomez, Markita Patricia Landry, Michael S. Strano
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Abstract
A single chirality single walled carbon nanotubes (SWNT), and combinations thereof, can be used to detect trace levels of chemical compounds in vivo with high selectivity.
Claims53
A composition comprising:
- a first plurality of nanoparticles having a first chirality;
- and
- a second plurality of nanoparticles having a second chirality.
A composition, comprising:
- a photocatalytic unit including an outer lipid membrane, and a plurality of nanoparticles having a single chirality contained within the outer lipid membrane of the photocatalytic unit.
-36. (canceled)
A method for monitoring activity in a sample, comprising:
- contacting a composition including a first plurality of nanoparticles having a first chirality;
- and a second plurality of nanoparticles having a second chirality with the sample;
- measuring the photoluminescence emission of the composition at a first time point;
- measuring the photoluminescence emission of the composition at a second time point;
- and
- comparing the photoluminescence emission measured at the first time point to the photoluminescence emission measured at the second time point, wherein a change in the photoluminescence emission between the first time point and the second time point indicates a change in a stimulus within the sample.
3 more elements
A method for monitoring a sample, comprising:
- introducing a plurality of a first photoluminescent nanoparticle into the sample, wherein the first plurality of photoluminescent nanoparticle has a first chirality;
- introducing a plurality of a second photoluminescent nanoparticle into the sample, wherein the second plurality of photoluminescent nanoparticle has a second chirality;
- measuring the photoluminescence emission of the first plurality of photoluminescent nanoparticles and the second plurality of photoluminescent nanoparticles at a first time point;
- measuring the photoluminescence emission of the first plurality of photoluminescent nanoparticles and the second plurality of photoluminescent nanoparticles at a second time point;
- comparing the photoluminescence emission measured at the first time point to the photoluminescence emission measured at the second time point for the first plurality of photoluminescent nanoparticle;
- and
- comparing the photoluminescence emission measured at the first time point to the photoluminescence emission measured at the second time point for the second plurality of photoluminescent nanoparticle,
- wherein a change in the photoluminescence emission between the first time point and the second time point indicates a change in a stimulus within the sample.
5 more elements
A method of separating a plurality of nanoparticles comprising:
- suspending the plurality of nanoparticles in an aqueous medium with a surfactant;
- sonicating the medium of the plurality of nanoparticles;
- adding a polymer to the medium;
- and
- adding an alcohol dropwise while maintaining the mixing of alcohol and the medium.
2 more elements
Dependencies are inferred from the claim text.