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US 2017/0291908 A1Published application
Substituted benzothiophenyl derivatives as gpr40 agonists for the treatment of type ii diabetes
AssigneeJanssen Pharmaceutica NV
InventorsSanath Meegalla, Mark R. Player, Hui Huang, Michael P. Winters
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein U1, U2, U3, R1, R2, Z, and W are defined herein.
Claims25
A compound of Formula (I)
- wherein
- U1 is N or C(R1), wherein R1 is selected from the group consisting of hydrogen, fluoro, chloro, or methyl;
- U2 and U3 are independently selected from CH or N, such that only up to one of U1, U2, and U3 is N in any instance;
- R2 is selected from the group consisting of hydrogen, methyl, chloro, fluoro, bromo, iodo, trifluoromethyl, cyano, and C1-4alkylsulfonyl;
- W is selected from the group consisting of
- i) hydrogen;
- wherein ring G is selected from the group consisting of phenyl, pyridyl, pyrazinyl, and pyrimidinyl;
- and, when ring G is phenyl, substituents R3 and R5 are optionally taken together with the atoms to which they are attached to form an unsubstituted or substituted bicyclic ring system selected from dihydrobenzo[b][1,4]dioxin-5-yl, 2,2,-dimethylchroman-5-yl, or (1-ethylcarboxy-indolin-4-yl);
- wherein R3 is selected from the group consisting of hydrogen, chloro, C1-4alkyl, 1,1-dioxidotetrahydro-2H-thiopyran-4-yl, 1,1-dioxido-3,6-dihydro-2H-thiopyran-4-yl, C1-3alkylsulfonyl, C1-3alkylsulfonylamino, and —OR4;
- wherein R4 is
- i) C1-8alkyl optionally independently substituted with one or two C1-3alkoxy or hydroxy substituents;
- ii) 4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-ylmethyl;
- iii) 1,1-dioxidotetrahydro-2H-thiopyran-4-yl;
- iv) tetrahydro-2H-pyran-4-yl;
- v) C1-3alkylsulfonylpropyl;
- or
- vi) (3-methyl-1,1-dioxidothietan-3-yl)methyl;
- wherein R5 is methyl, bromo, chloro, or trifluoromethyl;
- iii) C3-8cycloalkyl;
- wherein X1 is selected from the group consisting of CH2, O, S, NH, and N(C1-4alkyl);
- and wherein Rv is hydrogen or methyl;
- wherein V1 and V2 are independently selected from CH or N;
- and
- vi) C1-6alkyl;
- Z is CH or N;
- or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.
23 more elements
A compound of Formula (I)
- wherein
- U1 is N or C(R1), wherein R1 is hydrogen, fluoro, or chloro;
- U2 and U3 are independently selected from CH or N, such that only up to one of U1, U2, and U3 is N in any instance;
- R2 is selected from the group consisting of hydrogen, methyl, chloro, fluoro, bromo, iodo, trifluoromethyl, and cyano;
- W is selected from the group consisting of
- wherein ring G is selected from the group consisting of phenyl, pyridyl, and pyrimidinyl;
- and, when ring G is phenyl, substituents R3 and R5 are optionally taken together with the atoms to which they are attached to form an unsubstituted or substituted bicyclic ring system selected from dihydrobenzo[b][1,4]dioxin-5-yl, or (1-ethylcarboxy-indolin-4-yl);
- wherein R3 is selected from the group consisting of hydrogen, chloro, C1-4alkyl, 1,1-dioxido-3,6-dihydro-2H-thiopyran-4-yl, and —OR4;
- wherein R4 is
- i) C1-8alkyl independently substituted with one or two C1-3alkoxy or hydroxy substituents;
- ii) 1,1-dioxidotetrahydro-2H-thiopyran-4-yl;
- iii) C1-3alkylsulfonylpropyl;
- or
- iv) (3-methyl-1,1-dioxidothietan-3-yl)methyl;
- wherein R5 is methyl, bromo, chloro, or trifluoromethyl;
- ii) C5-8cycloalkyl;
- wherein X1 is selected from the group consisting of CH2, O, S, NH, and N(C1-4alkyl);
- and wherein Rv is hydrogen or methyl;
- wherein V1 and V2 are independently selected from CH or N;
- and
- v) C1-6alkyl;
- Z is CH or N;
- or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.
20 more elements
A compound of Formula (I)
- wherein
- U1 is N or C(R1), wherein R1 is hydrogen, fluoro, or chloro;
- U2 is independently selected from CH or N;
- U3 is CH, such that only one of U1 and U2 is N in any instance;
- R2 is selected from the group consisting of hydrogen, methyl, chloro, fluoro, bromo, iodo, trifluoromethyl, and cyano;
- W is selected from the group consisting of
- wherein ring G is selected from the group consisting of phenyl, pyridyl, and pyrimidinyl;
- and, when ring G is phenyl, substituents R3 and R5 are optionally taken together with the atoms to which they are attached to form an unsubstituted or substituted bicyclic ring system selected from dihydrobenzo[b][1,4]dioxin-5-yl, or (1-ethylcarboxy-indolin-4-yl);
- wherein R3 is selected from the group consisting of hydrogen, chloro, C1-4alkyl, 1,1-dioxido-3,6-dihydro-2H-thiopyran-4-yl, and —OR4;
- wherein R4 is
- ii) C1-6alkyl independently substituted with one or two C1-3alkoxy substituents;
- iii) 1,1-dioxidotetrahydro-2H-thiopyran-4-yl;
- iv) C1-3alkylsulfonylpropyl;
- or
- v) (3-methyl-1,1-dioxidothietan-3-yl)methyl;
- wherein R5 is methyl, bromo, chloro, or trifluoromethyl;
- wherein X1 is selected from the group consisting of CH2, O, S, NH, and N(C1-4alkyl);
- and wherein Rv is hydrogen or methyl;
- and
- wherein V1 is independently selected from CH or N, and V2 is CH;
- Z is CH or N;
- or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.
19 more elements
A compound of Formula (I)
- wherein
- U1 is N or C(R1), wherein R1 is hydrogen, fluoro, or chloro;
- U2 is independently selected from CH or N;
- U3 is CH, such that only one of U1 and U2 is N in any instance;
- R2 is selected from the group consisting of hydrogen, chloro, fluoro, bromo, trifluoromethyl, and cyano;
- W is selected from the group consisting of
- wherein ring G is selected from the group consisting of phenyl and pyridyl;
- and, when ring G is phenyl, substituents R3 and R5 are optionally taken together with the atoms to which they are attached to form (1-ethylcarboxy-indolin-4-yl);
- wherein R3 is selected from the group consisting of hydrogen, and —OR4;
- wherein R4 is
- i) C1-6alkyl independently substituted with one or two C1-3alkoxy substituents;
- ii) C1-3alkylsulfonylpropyl;
- or
- iii) (3-methyl-1,1-dioxidothietan-3-yl)methyl;
- wherein R5 is methyl, bromo, chloro, or trifluoromethyl;
- Z is CH or N;
- or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.
14 more elements
A compound of Formula (I)
- wherein
- U1 is N or C(R1), wherein R1 is hydrogen, methyl, fluoro, or chloro;
- U2 is independently selected from CH or N;
- U3 is CH or N, such that only one of U1 and U2 is N in any instance;
- R2 is selected from the group consisting of hydrogen, chloro, fluoro, bromo, iodo, methyl, methanesulfonyl, trifluoromethyl, and cyano;
- W is selected from the group consisting of 2-methylphenyl, 2-bromophenyl, 2-chloro-5-methylpyridin-4-yl, 2-methyl-4-(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxyphenyl, 2-methyl-4-(3-methyl-3-hydroxybutoxy)phenyl, 2-methyl-4-(2-methoxyethoxy)phenyl, 2-methyl-4-(tetrahydro-2H-pyran-4-yloxy)phenyl, 2-methyl-3-(2-methoxyethoxy)phenyl, 2-methylpyridin-3-yl, 2-methyl-4-(3-methyl-1,1-dioxidothietan-3-yl)methoxy)phenyl, 2-trifluoromethylphenyl, 2-methyl-4-(methyl sulfonyl)phenyl, 2-methyl-5-(2-methoxyethoxy)phenyl, 2-methyl-4-(3-methanesulfonylpropyloxy)phenyl, 2-methyl-4-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)phenyl, 2-methyl-4-(1,1-dioxidotetrahydro-2H-thiopyran-4-yloxy)phenyl, 2,6-dimethylphenyl, 2-(2-methoxyethoxy)-4-methylpyridin-5-yl, 1-methyl-1H-pyrazol-5-yl, 1-methyl-1H-1,2,4-triazol-5-yl, 4-methylpyrimidin-5-yl, 5-(2-methoxyethoxy)-3-methylpyridin-2-yl, dihydrobenzo[b][1,4]dioxin-5-yl, 1-(ethylcarboxy)-indolin-4-yl, 2-methyl-5-(methanesulfonylamino)phenyl, 2,2,-dimethylchroman-5-yl, 2-methyl-4-(2,3-dihydroxy-propyloxy)phenyl, 2-chlorophenyl, 5-(2-methoxyethoxy)-2-methylpyridin-3-yl, cyclopropyl, cyclohexyl, cyclopentyl, isopropyl, 2-methylpiperidin-1-yl, 2-methyl-4-methoxyphenyl, n-propyl, hydrogen, and n-butyl;
- Z is CH or N;
- or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof.
5 more elements
A compound of Formula (I)
- selected from the group consisting of
- (2S)-5-(2-(4-((3-(2-Methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- 5-((2S)-2-(4-((2-Chloro-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-ynyl)-1H-tetrazole;
- 5-((2S)-2-(4-((2-Fluoro-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-ynyl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(2-Bromophenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-4-(5-((4-(1-(1H-tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-2-chloro-5-methylpyridine;
- (2S)-4-((4-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-3-methylphenoxy)methyl)-4-hydroxytetrahydro-2H-thiopyran 1,1-dioxide;
- (2S)-4-(4-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-3-methylphenoxy)-2-methylbutan-2-ol;
- (2S)-5-(2-(4-((3-(4-(2-Methoxyethoxy)-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(2-Methyl-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(3-(2-Methoxyethoxy)-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-3-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-2-methylpyridine;
- (2S)-3-((4-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-3-methylphenoxy)methyl)-3-methylthietane 1,1-dioxide;
- (2S)-5-(2-(4-((3-(2-(Trifluoromethyl)phenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(2-Methyl-4-(methylsulfonyl)phenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(5-(2-Methoxyethoxy)-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(2-Methyl-4-(3-(methyl sulfonyl)propoxy)phenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-4-(4-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-3-methylphenyl)tetrahydro-2H-thiopyran 1,1-dioxide;
- 4-(4-(5-((4-((2S)-1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)-2-methylbenzo[b]thiophen-3-yl)-3-methylphenoxy)tetrahydro-2H-thiopyran 1,1-dioxide;
- 5-((2S)-2-(4-((2-Methyl-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-ynyl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(2,6-Dimethylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-2-(2-methoxyethoxy)-4-methylpyridine;
- (2S)-5-(2-(4-((3-(1-Methyl-1H-pyrazol-5-yl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(1-Methyl-1H-1,2,4-triazol-5-yl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-2-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-3-methylpyrazine;
- (2S)-5-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-4-methylpyrimidine;
- (2S)-2-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)-methyl)benzo[b]thiophen-3-yl)-5-(2-methoxyethoxy)-3-methylpyridine;
- (2S)-5-(2-(4-((3-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-1-(4-(5-((4-(1-(1H-tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)indolin-1-yl)propan-1-one;
- (2S)-N-((3-(5-((4-(1-(1H-tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-4-methylphenyl)methanesulfonamide;
- (2S)-5-(2-(4-((3-(2,2-dimethylchroman-5-yl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- 3-(4-(5-((4-((2S)-1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-3-methylphenoxy)propane-1,2-diol;
- (2S)-5-(2-(4-((3-(2-Chlorophenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-3-(5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-5-(2-methoxyethoxy)-2-methylpyridine;
- 5-((2S)-2-(4-((2-Bromo-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-ynyl)-1H-tetrazole;
- 5-((2S)-2-(4-((2-Iodo-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-ynyl)-1H-tetrazole;
- 5-((2S)-2-(4-((2-Trifluoromethyl-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-ynyl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-Cyclopropyl-2-(trifluoromethyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- 5-((2S)-2-(4-((2-Cyano-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((2-(Methyl sulfonyl)-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2R)-5-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)-2-((3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)pyridine;
- (2R)-5-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)-2-((3-(4-(2-methoxyethoxy)-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)pyridine;
- (2R)-5-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)-2-((3-(3-(2-methoxyethoxy)-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)pyridine;
- (2R)-4-(4-(5-(((5-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)pyridin-2-yl)oxy)methyl)-benzo[b]thiophen-3-yl)-3-methylphenoxy)-2-methylbutan-2-ol;
- (2S)-5-(2-(4-((2-Fluoro-3-(4-(2-methoxyethoxy)-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((2-Chloro-3-(4-(2-methoxyethoxy)-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-(4-(2-Methoxyethoxy)-2-methylphenyl)-2-methylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- 5-((2S)-2-(4-((3-(4-(2-Methoxyethoxy)-2-methylphenyl)-2-(trifluoromethyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- 1-(5-((4-((2S)-1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)benzo[b]thiophen-3-yl)-2-methylpiperidine;
- (2S)-5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)-3-(2-methylphenyl)thieno[2, 3-b]pyridine;
- (2S)-5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)-3-(4-methoxy-2-methylphenyl)thieno[2, 3-b]pyridine;
- (2S)-5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)-3-(2-methylphenyl)thieno[2, 3-c]pyridine;
- (2S)-5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)-3-(4-methoxy-2-methylphenyl)thieno[2, 3-c]pyridine;
- (2S)-5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)-3-(2-methylphenyl)thieno[3,2-b]pyridine;
- (2S)-5-((4-(1-(1H-Tetrazol-5-yl)pent-3-yn-2-yl)phenoxy)methyl)-3-(4-methoxy-2-methylphenyl)thieno[3,2-b]pyridine;
- (2S)-5-(2-(4-((3-Cyclohexylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-Cyclopentylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-Cyclopropylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-Isopropylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-Propylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-(Benzo[b]thiophen-5-ylmethoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2RS)-5-(2-(4-((3-(2-Methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2R)-5-(2-(4-((3-(2-Methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((7-Methyl-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-Butyl-7-methylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-Cyclopentyl-7-methylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((3-Cyclohexyl-7-methylbenzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((7-Chloro-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((7-Chloro-3-(4-methoxy-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((7-Fluoro-3-(2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole;
- (2S)-5-(2-(4-((7-Fluoro-3-(4-methoxy-2-methylphenyl)benzo[b]thiophen-5-yl)methoxy)phenyl)pent-3-yn-1-yl)-1H-tetrazole
- or a pharmaceutically acceptable salt form thereof.
69 more elements
Dependencies are inferred from the claim text.