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US 2017/0291904 A1Published application
Compounds and methods
AssigneeIntra-Cellular Therapies, Inc.
InventorsPeng LI, Hailin ZHENG, Jun ZHAO, Lawrence WENNOGLE
Life of this patent
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Abstract
The subject matter generally relates to compounds and methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective agents and/or neural regenerative agents. In a further aspect, the subject matter relates to individuals that are at risk for the development of CNS disease or disorder.
Claims25
A compound of Formula V
- wherein
- (i) R1 is C1-4 alkyl;
- (ii) R4 is H and R2 and R3 are, independently, H or C1-4 alkyl;
- (iii) R5 is attached to one of the nitrogens on the pyrazolo portion of Formula V and is a moiety of Formula A
- wherein X, Y and Z are C, and R8, R9, R11 and R12 are H, and R10 is halogen, or heteroaryl optionally substituted with halogen, alkyl, haloalkyl, hydroxy or carboxy;
- and
- (iv) R6 is H, C1-4alkyl, arylamino optionally substituted with C1-4alkyl or halogen;
- and
- (v) n=0;
- in free or pharmaceutically acceptable salt form.
7 more elements
Dependencies are inferred from the claim text.