Substituted pyridine-piperazinyl analogues as rsv antiviral compounds
AssigneeJanssen Sciences Ireland UC
InventorsJerôme Emile Georges GUILLEMONT, David Francis Alain LANÇOIS, Magali Madeleine Simone MOTTE, Delphine Yvonne Raymonde LARDEAU, Xavier Marc BOURDREZ, Wendy Mia Albert BALEMANS, Dirk André Emmy ROYMANS
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Abstract
The invention concerns novel substituted pyridine-piperazinyl analogues of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
Claims15
-14. (canceled)
A compound of the following formula
- or a stereochemically isomeric form thereof, wherein
- X is CR6, and Y is N, wherein R6 is hydrogen;
- R1 and R2 are hydrogen;
- R3 is hydrogen;
- R4 is hydrogen;
- L1 is a direct bond;
- L2 is a direct bond;
- and
- R5 is heteroaryl;
- wherein each heteroaryl is optionally substituted with one or two substituents each independently selected from the group consisting of:
- C1-4alkyl, C1-4alkyloxy, hydroxyC1-4alkyl, cyanoC1-4alkyl, polyhaloC1-4alkyl, and C1-4alkyloxyC1-4alkyl;
- or a pharmaceutically acceptable acid addition salt thereof.
A compound selected from the group consisting of:
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.